9/1/2023 0 Comments Scaffold pouch![]() ![]() Bone can be taken from several areas e.g., iliac crest or fibula, depending on the severity and amount needed for reconstruction of the defect. This procedure necessitates harvesting the patient’s own bone and subsequently transplanting it to the defect site. Autologous bone grafting is still considered the gold standard treatment due to its osteoconductive, osteoinductive and osteogenic properties. Notably, the successful repair of large bone defects caused by trauma, tumor resection or disease remains a clinical challenge for orthopedic and plastic surgeons and often requires additional treatments. However, there are some conditions in which bone regeneration is delayed, compromised or beyond the physiological healing potential 1, 2. Taken together, this pilot study demonstrated the feasibility of precised pre-surgical planning and reconstruction of large bone defects with 3D-printed personalized scaffolds.īone is a dynamic tissue that possesses the intrinsic capacity to heal within 6–8 weeks after immobilization of a fracture. ![]() ![]() Histology confirmed bone growth inside the porous 3D scaffolds with or without vascular pedicle inclusion. The presence of the vascular pedicle further enhanced bone formation. After 3 months, the untreated defect remained non-bridged while the 3D scaffold guided bone regeneration. Bone regeneration was evaluated 1, 2 and 3 months post-implantation. Critical-sized segmental defects created in the mid-diaphyseal region of the metatarsus were either left empty or treated with the 3D scaffold alone or in combination with an axial vascular pedicle. ![]() Pre-operative computed tomography scans were performed to visualize the metatarsus and vasculature and to fabricate customized scaffolds and surgical guides by 3D printing. This pilot study aimed to investigate the feasibility of regenerating large bone defects in sheep using 3D-printed customized calcium phosphate scaffolds with or without surgical vascularization. Successful bone repair also depends on sufficient vascularization and to address this challenge, novel strategies focus on the development of vascularized biomaterial scaffolds. Manipulation of the microenvironment of transplanted islets may constitute the basis for new approaches to enhance islet engraftment.Although autografts are considered to be the gold standard treatment for reconstruction of large bone defects resulting from trauma or diseases, donor site morbidity and limited availability restrict their use. These results indicate that biodegradable scaffolds may enhance survival and function of islet grafts. Histological examination of the grafts in the scaffold showed numerous well-granulated, insulin-containing cells as well as glucagon-positive cells. In contrast, two dogs transplanted with a similar marginal mass without the scaffold never became normoglycemic. In two out of the three that received a marginal islet mass, insulin independence was sustained up to 2 months. One dog, transplanted with the largest number of islets, maintained a normal metabolic state until the graft was removed at 5 months posttransplant. All four animals that received islets in the scaffold became normoglycemic without exogeneous insulin injection. Four dogs received islets seeded in a biodegradable polymer scaffold and two received free islets without a scaffold. Six beagle dogs underwent total pancreatectomy followed by islet autotransplantation into the omental pouch. The aim of this study was to investigate whether the use of a medically approved biodegradable scaffold as a solid support system would enhance graft survival following transplantation into the omental pouch in a preclinical large animal model. ![]()
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